ESIEE Paris · Open to a 6-month research internship · Clinical NLP & Biomedical AI · from Feb 2027

Extracting biomarkers from clinical text without waking the GPU

I'm Clément Longeac. I build DEMNE, a routing framework that picks, per entity type, the lightest method that stays reliable — rules, a transformer, or an LLM. On an unseen AP-HP cohort it routes 99.5% of mentions to auditable rules at F1 0.941, where a fine-tuned transformer reaches 0.358.

DEMNE routing decision graph: entity metrics route to RULES, TBM or LLM
DEMNE — decision graph: entity metrics route to Rules, TBM or LLM

From tutoring math to modeling tumor markers

I'm a fifth-year student at ESIEE Paris, specializing in Data Science & AI, and enrolled in the school's Tremplin Recherche track — a program built for students heading toward doctoral research rather than a standard industry placement.

My work centers on making unstructured clinical text usable for research: extracting the biomarkers, staging information, and treatment details buried in French oncology reports, where general-purpose NLP tools consistently fail on domain vocabulary and document structure.

Alongside my studies I tutor mathematics and physics-chemistry through Complétude, and I'm preparing applications for a CIFRE industrial PhD in biomedical AI at Sorbonne University.

Clément Longeac
Institution
ESIEE Paris
Program
Data Science & AI (DSIA)
Track
Tremplin Recherche
Next step
PhD, biomedical AI — Sorbonne
Languages
FR · EN · JP · ES

DEMNE

A hybrid named-entity recognition pipeline for French oncology clinical text.

What the staged approach buys

0.0%

of mentions routed to rules on an unseen AP-HP cohort (411/413)

0.000

rule F1 vs 0.358 for a fine-tuned DrBERT, same entities

0.000

leave-one-corpus-out routing concordance

Determination of Extraction Methods for Named Entities

Clinical NER · French oncology corpora

Off-the-shelf NER models struggle badly on French clinical text: dense abbreviations, inconsistent formatting across hospital systems, and biomarker terminology that barely appears in general training data. DEMNE tackles this with a staged pipeline rather than a single model — each stage handles what it's actually good at, and only escalates to a heavier model when it has to.

The system is fine-tuned on DrBERT-7GB across three distinct French oncology corpora, and targets seven priority biomarker entity types used in treatment-relevant reporting.

Clinical NLPTransformersDrBERT-7GBFrench oncology
01

Rule-based pass

Regex and lexicon matching catch high-confidence, low-ambiguity entities cheaply — dates, dosages, standard biomarker abbreviations.

02

Transformer extraction

DrBERT-7BG, fine-tuned across three oncology corpora, handles the entities that need real semantic and domain understanding.

03

LLM arbitration

Remaining conflicts and edge cases are routed to an LLM pass for final disambiguation before output.

Regulatory alignment — EU AI Act

Clinical entity extraction over patient records sits squarely inside the EU AI Act's high-risk category. DEMNE's staged design keeps Articles 12 and 14 in mind from the start, not bolted on after the fact.

Art. 12 — Record-keeping

Every extraction decision is traceable to the stage (rules, transformer, or LLM) and confidence score that produced it, enabling automatic audit logging.

Art. 14 — Human oversight

LLM arbitration outputs are flagged for clinician review rather than silently accepted, keeping a human in the loop on ambiguous cases.

Where the work has happened so far

May — Jul 2026

Research Intern, Clinical Data Warehouse

AP-HP (Assistance Publique – Hôpitaux de Paris)

Applied and validated the DEMNE routing approach on hospital data: extracting oncology biomarkers (ER, PR, HER2, Ki67, FISH) from French clinical reports, and defining an auditable, deployment-realistic clinical path.

Clinical NLPEDS-NLPBRAT / CoNLLPythonDrBERT
Oct 2025 — May 2026

Student Researcher, Tremplin Recherche

ESIEE Paris · LBA (Aix-Marseille) · AP-HP

Designed DEMNE, a hybrid clinical NER pipeline (rules / transformer / LLM) for French oncology text, driven by five formalized corpus metrics — the core project of the Tremplin Recherche track ahead of PhD applications.

PythonHugging FaceDrBERTpycrfsuiteeco2aiBRAT / CoNLLOptuna
2026 — PresentOngoing

Product Lead & Developer, NeuroStep

Junior Entreprise ESIEE Paris

Building a platform that gives brain-injury patients and occupational therapists a structured way to compare cognitive-compensation tools. Started as a Python/Streamlit prototype at the SN@SU hackathon (Sorbonne Université, with Flor Sanchez-Luizard, occupational therapist at UEROS L'ADAPT Île-de-France); now scoping a production rebuild (FastAPI, PostgreSQL, Next.js) with HDS/RGPD-compliant hosting and a semantic search engine for clinical tool matching.

PythonStreamlitFastAPIPostgreSQLNext.js
2024 — 2027

Engineering Student — Data Science & AI

ESIEE Paris

Fifth-year student in ESIEE Paris's five-year engineering program, specializing in Data Science & AI (DSIA).

Machine LearningDeep LearningData ScienceC / C++
2025

Engineering Intern, GRADES Division

Synchrotron SOLEIL

Developed autopkgtests using OpenCL for AMD GPU compatibility (pyopencl, nabu, ufo-filters, pyvkfft) across Debian/ROCm infrastructure on GitLab Salsa.

OpenCLPythonBashDebianGitLab CIROCm
2022 — Present

STEM Tutor

Complétude

Teaching mathematics and physics-chemistry to about ten students, from primary school through terminale, alongside my engineering studies.

MathematicsPhysicsPedagogy

Technical Stack

Tools grouped by how they matter to the work above — not a generic list.

Clinical NLP & Biomedical AI

DrBERT-7GB · CamemBERT · spaCy · HuggingFace Transformers
Regex/lexicon design · Optuna (NSGA-II) · BRAT / CoNLL
Clinical text preprocessing · Domain adaptation

Systems & Infrastructure

Python · FastAPI · PostgreSQL · Docker · Kubernetes
Linux · Debian · GitLab CI · GitHub Actions
OpenCL · pyopencl · ROCm · CUDA (basic)

Research Tooling

PyTorch · LaTeX/Overleaf · TikZ · Zotero
Jupyter · pandas · NumPy · matplotlib

Languages

🇫🇷 Native · 🇬🇧 C1 · 🇯🇵 Intermediate · 🇪🇸 B2 · 🇮🇹 In progress

Areas of Focus

I

Clinical Named Entity Recognition

Extracting biomarkers, staging, and treatment data from unstructured French oncology text. Where general-purpose NLP breaks and domain adaptation begins.

II

Frugal & Interpretable AI

Designing systems that route to the least opaque tier meeting performance thresholds. Compliance with the EU AI Act as a design constraint, not an afterthought.

III

Multimodal Biomedical Reasoning

Long-term direction: unifying clinical text, imaging, and genomics into models that reason across modalities. The world-models direction applied to medicine.

IV

Pedagogy of Complex Systems

Teaching mathematics and physics-chemistry to about ten students at Complétude, from primary school through terminale. Making dense concepts learnable is a research skill, not a side gig.

Let's talk about clinical NLP, biomedical AI, or a PhD collaboration.

Book a call →